|
In vitro Services
1. Absorption
1.1. Caco-2 Permeability Assay
2. Metabolic Stability
2.1. Drug Discovery Screen
2.2. Drug Development Assay
3. CYP Profiling
3.1. Human Recombinant Enzymes
3.2. Chemical Inhibition
3.3. Correaltion Analysis
4. Enzyme Kinetics
5. Species Comparison and Metabolite Profiling
5.1. Available Species, Strains and Test Systems
5.2. Study Outline
6. CYP Inhibition
6.1. Drug Discovery Screen
6.2. Determination of the IC50
6.3. Determination of the Ki
7. CYP Induction
In vivo Services
1. General Considerations
1.1. Animal Welfare
1.2. Homogeneity and Stability
2. Pharmacokinetics
|
