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Micronucleus Test
The micronucleus test in vitro detects clastogenic effects of the test item in mammalian cells. The test is performed according to the OECD draft guideline by J. M. Parry. Screening and ranking study designs are also available.
Advanced Micronucleus Test (V79 Cell BatteryTM, OECD Guideline by J. M. Parry)
Quantity of test item required: 2 g
Turnaround time of draft report : 20 working days
Study Design
- cytotoxicity and range finding pre-test
- recombinant V79 cells expressing phase I and / or phase II enzymes (see V79 Cell BatteryTM)
- internal metabolic activation
- duplicates
- three dose levels
- incubation time: 24 - 72 h
- negative control
- positive control
- microscopic analysis: 1000 cells per duplicate
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