Chromosome Aberration Test

The chromosome aberration test (mutagenicity: in vitro mammalian cytogenetic test) is performed according to OECD guideline 473. Screening and ranking study designs are also available.

Standard Chromosome Aberration Test (OECD 473)

Quantity of test item required: 3 g
Turnaround time of draft report : 30 working days

Study Design

• cytotoxicity and range finding pre-test
• V79 cells
• three dose levels
• minimum of two replicates per dose level
• with and without rat S9
• incubation time: 3 h w and w/o S9, 24 h w/o S9
• negative control
• positive control
• evaluation of 200 metaphases per concentration

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