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Chromosome Aberration Test
The chromosome aberration test (mutagenicity: in vitro mammalian cytogenetic test) is performed according to OECD guideline 473. Screening and ranking study designs are also available.
Advanced Chromosome Aberration Test (V79 Cell BatteryTM, OECD 473)
Quantity of test item required: 2 g
Turnaround time of draft report : 30 working days
Study Design
- cytotoxicity and range finding pre-test
- recombinant V79 Cell BatteryTM cells expressing phase I and / or phase II enzymes (see V79 Cell BatteryTM)
- internal metabolic activation
- three dose levels
- minimum of two replicates per dose level
- incubation time: 24 - 72 h
- negative control
- positive control
- evaluation of 200 metaphases per concentration
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