Early ADME-Tox Test Strategy

Early Metabolism Testing

Information

Selective Detection of NCE

Phase I Metabolism: CYP Dependent Metabolism

Identification of Critical CYPs:

• 2C9, 2D6 and 3A4 Metabolize ca. 95% of all Drugs
• 2C9 und 2D6 are Polymorphic
• 3A4 is frequently involved in Drug-Drug Interactions

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