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Dermatology / Cosmetics
The oral services are offered in co-operation with VivaCell.
Oral Care: in vitro Services
Models
- human primary monocytes
- human normal fibroblast monolayer cultures (comparable to gingival fibroblast)
- primary oral gingival epithelial cells (treated with pathogens) cell lines:
- fibroblasts (MRC5, 3T3), etc.
- VR I transfected cells: activation of these cells through this nociceptive receptor could mimic the initial steps in neurogenic inflammation and it is suitable to test new analgesic compounds topically applied in oral care
Parameters
- inflammatory parameters: PGE2, LTB4, cytokines, etc.
- cytotoxicity: MTT, LDH, Neutral Red, etc.
- oxygen radical production
- cell proliferation
- angiogenesis
- healing and migration
- calcium mobilisation and cell death through agonists / antagonist of the VR I in a heterolgous system
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