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Central Nervous System
The CNS services are offered in co-operation with VivaCell.
CNS: in vivo Services
Highly specialised and reliable perclinical in vivo disease models for drug development are offered.
Stroke
- transient or permanent occlusion of the middle cerebral artery in rat, mouse and transgenic rodents, focal ischemia in gerbils
Cardiac Arrest
- occlusion of both carotid and vertebral arteries in rat and mouse
Head Trauma
- controlled cortical impact injury in rat and mouse
Spinal Cord Trauma
- with a spinal cord impactor in rat
Parkinson's Disease
- intracerebral injection of 6-OH dopamine in rat and mouse
Epilepsy
- systemic / hippocampal kainic acid injection in rat and mouse
Huntington's Disease
- intrastriatal injection of quinolinate in rat and mouse
Migraine
- spreading depression induced by KCI in rat and mouse
Brain Edema
- cold-injury-induced in rat and mouse
Neuromuscular and Neurological Models
- multiple sclerosis (EAE), transgenic models for ALS
- inherited murine models of motoneuron diseases
Peripher Neuropathy
- sciatic nerve crush
- diabeitc rats (streptozotocin induction)
- acrylamide and cisplatin-induced neuropathies
Pain
Anxiety
- free exploratory test
- white / dark box
- elevated plus maze
- open-field
Depression
- chronic mild stress
- forced swim test
Schizophrenia
- prepulse inhibition memory and amnesia
- conditioned avoidance responses (passive avoidance)
- maze learning tasks (radial maze, T-maze)
- object recognition task
- spontaneous and delayed alternation tasks (T-maze)
- operant bar-press task
Anhedonia, Hedonia
- place preference conditioning
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